Sri and Sweta have published two recent papers detailing the thermodynamic and structural properties of geranylated RNAs in NAR and Chem Comm. This is all part of a long-term collaboration with Jia Sheng’s lab to detail the structure and function of naturally occuring, chemically modified RNAs, including 5-hydroxymethyl cytosine. Congrats!

  1. Wang, Rui.; Vangaveti, Sweta ; Ranganathan, Sri; Basanta-Sanchez, Maria; Haruehanroengra, Phensinee ; Chen, Alan;and Sheng, Jia (2016) “Synthesis, Base Pairing and Structure Studies of Geranylated RNA” (2016) Nucleic Acids Research 44 (13): 6036-6045.  doi: 10.1093/nar/gkw544
  2. R. Wang, S. Ranganathan, M. Basanta Sanchez, F. Shen, A. Chen and J. Sheng, (2015), Synthesis and Base Pairing Studies of Geranylated 2-thiothymidine, a Natural Variant of Thymidine. Chem. Commun., (51) 16369-16372 DOI:10.1039/C5CC07479G
  3. 6. R. Wang, S. Ranganathan, V. A. Valsankar, S. M. Magliocco, F. Shen, A. Chen and J. Sheng, (2015), Water-bridged hydrogen bond formation between 5-hydroxymethylcytosine (5-hmC) and its 3’-neighboring bases in A- and B-form DNA Duplexes. Chem. Commun., (51) 16389-16392 DOI: 10.1039/C5CC06563A